Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction i...

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Detalles Bibliográficos
Autores principales: Pezato, Rogério, Balsalobre, Leonardo, Lima, Milena, Bezerra, Thiago F P, Voegels, Richard L, Gregório, Luis Carlos, Stamm, Aldo Cassol, Zele, Thibaut van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651231/
https://www.ncbi.nlm.nih.gov/pubmed/23663431
http://dx.doi.org/10.1186/1916-0216-42-27
Descripción
Sumario:This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.

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