Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction i...

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Autores principales: Pezato, Rogério, Balsalobre, Leonardo, Lima, Milena, Bezerra, Thiago F P, Voegels, Richard L, Gregório, Luis Carlos, Stamm, Aldo Cassol, Zele, Thibaut van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651231/
https://www.ncbi.nlm.nih.gov/pubmed/23663431
http://dx.doi.org/10.1186/1916-0216-42-27
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author Pezato, Rogério
Balsalobre, Leonardo
Lima, Milena
Bezerra, Thiago F P
Voegels, Richard L
Gregório, Luis Carlos
Stamm, Aldo Cassol
Zele, Thibaut van
author_facet Pezato, Rogério
Balsalobre, Leonardo
Lima, Milena
Bezerra, Thiago F P
Voegels, Richard L
Gregório, Luis Carlos
Stamm, Aldo Cassol
Zele, Thibaut van
author_sort Pezato, Rogério
collection PubMed
description This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
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spelling pubmed-36512312013-05-14 Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling Pezato, Rogério Balsalobre, Leonardo Lima, Milena Bezerra, Thiago F P Voegels, Richard L Gregório, Luis Carlos Stamm, Aldo Cassol Zele, Thibaut van J Otolaryngol Head Neck Surg Review This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process. BioMed Central 2013-03-28 /pmc/articles/PMC3651231/ /pubmed/23663431 http://dx.doi.org/10.1186/1916-0216-42-27 Text en Copyright © 2013 Pezato et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Pezato, Rogério
Balsalobre, Leonardo
Lima, Milena
Bezerra, Thiago F P
Voegels, Richard L
Gregório, Luis Carlos
Stamm, Aldo Cassol
Zele, Thibaut van
Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_full Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_fullStr Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_full_unstemmed Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_short Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
title_sort convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to staphylococcus aureus and airway remodeling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651231/
https://www.ncbi.nlm.nih.gov/pubmed/23663431
http://dx.doi.org/10.1186/1916-0216-42-27
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