Tumor Environmental Factors Glucose Deprivation and Lactic Acidosis Induce Mitotic Chromosomal Instability – An Implication in Aneuploid Human Tumors

Mitotic chromosomal instability (CIN) plays important roles in tumor progression, but what causes CIN is incompletely understood. In general, tumor CIN arises from abnormal mitosis, which is caused by either intrinsic or extrinsic factors. While intrinsic factors such as mitotic checkpoint genes hav...

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Detalles Bibliográficos
Autores principales: Dai, Chunyan, Sun, Feifei, Zhu, Chunpeng, Hu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651256/
https://www.ncbi.nlm.nih.gov/pubmed/23675453
http://dx.doi.org/10.1371/journal.pone.0063054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651256/
https://www.ncbi.nlm.nih.gov/pubmed/23675453
http://dx.doi.org/10.1371/journal.pone.0063054

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