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Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure
BACKGROUND: In the last recent years a new percutaneous procedure, the MitraClip, has been validated for the treatment of mitral regurgitation. MitraClip procedure is a promising alternative for patients unsuitable for surgery as it reduces the risk of death related to surgery ensuring a similar res...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651274/ https://www.ncbi.nlm.nih.gov/pubmed/23642140 http://dx.doi.org/10.1186/1476-7120-11-13 |
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author | Guarracino, Fabio Ferro, Baldassare Baldassarri, Rubia Bertini, Pietro Forfori, Francesco Giannini, Cristina Di Bello, Vitantonio Petronio, Anna S |
author_facet | Guarracino, Fabio Ferro, Baldassare Baldassarri, Rubia Bertini, Pietro Forfori, Francesco Giannini, Cristina Di Bello, Vitantonio Petronio, Anna S |
author_sort | Guarracino, Fabio |
collection | PubMed |
description | BACKGROUND: In the last recent years a new percutaneous procedure, the MitraClip, has been validated for the treatment of mitral regurgitation. MitraClip procedure is a promising alternative for patients unsuitable for surgery as it reduces the risk of death related to surgery ensuring a similar result. Few data are present in literature about the variation of hemodynamic parameters and ventricular coupling after Mitraclip implantation. METHODS: Hemodynamic data of 18 patients enrolled for MitraClip procedure were retrospectively reviewed and analyzed. Echocardiographic measurements were obtained the day before the procedure (T0) and 21 ± 3 days after the procedure (T1), including evaluation of Ejection Fraction, mitral valve regurgitation severity and mechanism, forward Stroke Volume, left atrial volume, estimated systolic pulmonary pressure, non invasive echocardiographic estimation of single beat ventricular elastance (Es(sb)), arterial elastance (Ea) measured as systolic pressure • 0.9/ Stroke Volume, ventricular arterial coupling (Ea/Es(sb) ratio). Data were expressed as median and interquartile range. Measures obtained before and after the procedure were compared using Wilcoxon non parametric test for paired samples. RESULTS: Mitraclip procedure was effective in reducing regurgitation. We observed an amelioration of echocardiographic parameters with a reduction of estimated systolic pulmonary pressure (45 to 37,5 p = 0,0002) and left atrial volume (110 to 93 p = 0,0001). Despite a few cases decreasing in ejection fraction (37 to 35 p = 0,035), the maintained ventricular arterial coupling after the procedure (P = 0,67) was associated with an increasing in forward stroke volume (60,3 to 78 p = 0,05). CONCLUSION: MitraClip is effective in reducing mitral valve regurgitation and determines an amelioration of hemodynamic parameters with preservation of ventricular arterial coupling. |
format | Online Article Text |
id | pubmed-3651274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36512742013-05-11 Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure Guarracino, Fabio Ferro, Baldassare Baldassarri, Rubia Bertini, Pietro Forfori, Francesco Giannini, Cristina Di Bello, Vitantonio Petronio, Anna S Cardiovasc Ultrasound Research BACKGROUND: In the last recent years a new percutaneous procedure, the MitraClip, has been validated for the treatment of mitral regurgitation. MitraClip procedure is a promising alternative for patients unsuitable for surgery as it reduces the risk of death related to surgery ensuring a similar result. Few data are present in literature about the variation of hemodynamic parameters and ventricular coupling after Mitraclip implantation. METHODS: Hemodynamic data of 18 patients enrolled for MitraClip procedure were retrospectively reviewed and analyzed. Echocardiographic measurements were obtained the day before the procedure (T0) and 21 ± 3 days after the procedure (T1), including evaluation of Ejection Fraction, mitral valve regurgitation severity and mechanism, forward Stroke Volume, left atrial volume, estimated systolic pulmonary pressure, non invasive echocardiographic estimation of single beat ventricular elastance (Es(sb)), arterial elastance (Ea) measured as systolic pressure • 0.9/ Stroke Volume, ventricular arterial coupling (Ea/Es(sb) ratio). Data were expressed as median and interquartile range. Measures obtained before and after the procedure were compared using Wilcoxon non parametric test for paired samples. RESULTS: Mitraclip procedure was effective in reducing regurgitation. We observed an amelioration of echocardiographic parameters with a reduction of estimated systolic pulmonary pressure (45 to 37,5 p = 0,0002) and left atrial volume (110 to 93 p = 0,0001). Despite a few cases decreasing in ejection fraction (37 to 35 p = 0,035), the maintained ventricular arterial coupling after the procedure (P = 0,67) was associated with an increasing in forward stroke volume (60,3 to 78 p = 0,05). CONCLUSION: MitraClip is effective in reducing mitral valve regurgitation and determines an amelioration of hemodynamic parameters with preservation of ventricular arterial coupling. BioMed Central 2013-05-04 /pmc/articles/PMC3651274/ /pubmed/23642140 http://dx.doi.org/10.1186/1476-7120-11-13 Text en Copyright © 2013 Guarracino et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Guarracino, Fabio Ferro, Baldassare Baldassarri, Rubia Bertini, Pietro Forfori, Francesco Giannini, Cristina Di Bello, Vitantonio Petronio, Anna S Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure |
title | Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure |
title_full | Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure |
title_fullStr | Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure |
title_full_unstemmed | Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure |
title_short | Non invasive evaluation of cardiomechanics in patients undergoing MitrClip procedure |
title_sort | non invasive evaluation of cardiomechanics in patients undergoing mitrclip procedure |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651274/ https://www.ncbi.nlm.nih.gov/pubmed/23642140 http://dx.doi.org/10.1186/1476-7120-11-13 |
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