Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients

BACKGROUND: Previous research in animal seizure models indicates that the pleiotropic cytokine TNF is an important effector/mediator of neuroinflammation and cell death. Recently, it has been demonstrated that TNF downregulates Klotho (KL) through the nuclear factor kappa B (NFkB) system in animal m...

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Detalles Bibliográficos
Autores principales: Teocchi, Marcelo Ananias, Ferreira, Ana Érika Dias, da Luz de Oliveira, Evandro Pinto, Tedeschi, Helder, D’Souza-Li, Lília
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651326/
https://www.ncbi.nlm.nih.gov/pubmed/23634661
http://dx.doi.org/10.1186/1742-2094-10-53

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