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Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases

BACKGROUND: Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas....

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Autores principales: Ardengh, José Celso, Lopes, César Vivian, Kemp, Rafael, Venco, Filadélfio, de Lima-Filho, Eder Rios, dos Santos, José Sebastião
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651366/
https://www.ncbi.nlm.nih.gov/pubmed/23578194
http://dx.doi.org/10.1186/1471-230X-13-63
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author Ardengh, José Celso
Lopes, César Vivian
Kemp, Rafael
Venco, Filadélfio
de Lima-Filho, Eder Rios
dos Santos, José Sebastião
author_facet Ardengh, José Celso
Lopes, César Vivian
Kemp, Rafael
Venco, Filadélfio
de Lima-Filho, Eder Rios
dos Santos, José Sebastião
author_sort Ardengh, José Celso
collection PubMed
description BACKGROUND: Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas. METHODS: In a retrospective review, patients with pancreatic solid tumours and history of previous extrapancreatic cancer underwent EUS-FNA from January/1997 to December/2010. Most patients were followed-up until death and some of them were still alive at the end of the study. The performance of EUS-FNA for diagnosis of pancreatic metastases was analyzed. Symptoms, time frame between primary tumour diagnosis and the finding of metastases, and survival after diagnosis were also analyzed. RESULTS: 37 patients underwent EUS-FNA for probable pancreas metastases. Most cases (65%) presented with symptoms, especially upper abdominal pain (46%). Median time between detection of the first tumour and the finding of pancreatic metastases was 36 months. Metastases were confirmed in 32 (1.6%) cases, 30 of them by EUS-FNA, and 2 by surgery. Other 5 cases were non-metastatic. Most metastases were from lymphoma, colon, lung, and kidney. Twelve (32%) patients were submitted to surgery. Median survival after diagnosis of pancreatic metastases was 9 months, with no difference of survival between surgical and non-surgical cases. Sensitivity, specificity, positive and negative predictive values, and accuracy of EUS-FNA with histology analysis of the specimens for diagnosis of pancreatic metastases were, respectively, 93.8%, 60%, 93.8%, 60% and 89%. CONCLUSION: EUS-FNA with histology of the specimens is a sensitive and accurate method for definitive diagnosis of metastatic disease in patients with a previous history of extrapancreatic malignancies.
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spelling pubmed-36513662013-05-11 Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases Ardengh, José Celso Lopes, César Vivian Kemp, Rafael Venco, Filadélfio de Lima-Filho, Eder Rios dos Santos, José Sebastião BMC Gastroenterol Research Article BACKGROUND: Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas. METHODS: In a retrospective review, patients with pancreatic solid tumours and history of previous extrapancreatic cancer underwent EUS-FNA from January/1997 to December/2010. Most patients were followed-up until death and some of them were still alive at the end of the study. The performance of EUS-FNA for diagnosis of pancreatic metastases was analyzed. Symptoms, time frame between primary tumour diagnosis and the finding of metastases, and survival after diagnosis were also analyzed. RESULTS: 37 patients underwent EUS-FNA for probable pancreas metastases. Most cases (65%) presented with symptoms, especially upper abdominal pain (46%). Median time between detection of the first tumour and the finding of pancreatic metastases was 36 months. Metastases were confirmed in 32 (1.6%) cases, 30 of them by EUS-FNA, and 2 by surgery. Other 5 cases were non-metastatic. Most metastases were from lymphoma, colon, lung, and kidney. Twelve (32%) patients were submitted to surgery. Median survival after diagnosis of pancreatic metastases was 9 months, with no difference of survival between surgical and non-surgical cases. Sensitivity, specificity, positive and negative predictive values, and accuracy of EUS-FNA with histology analysis of the specimens for diagnosis of pancreatic metastases were, respectively, 93.8%, 60%, 93.8%, 60% and 89%. CONCLUSION: EUS-FNA with histology of the specimens is a sensitive and accurate method for definitive diagnosis of metastatic disease in patients with a previous history of extrapancreatic malignancies. BioMed Central 2013-04-11 /pmc/articles/PMC3651366/ /pubmed/23578194 http://dx.doi.org/10.1186/1471-230X-13-63 Text en Copyright © 2013 Ardengh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ardengh, José Celso
Lopes, César Vivian
Kemp, Rafael
Venco, Filadélfio
de Lima-Filho, Eder Rios
dos Santos, José Sebastião
Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
title Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
title_full Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
title_fullStr Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
title_full_unstemmed Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
title_short Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
title_sort accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651366/
https://www.ncbi.nlm.nih.gov/pubmed/23578194
http://dx.doi.org/10.1186/1471-230X-13-63
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