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Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases
BACKGROUND: Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651366/ https://www.ncbi.nlm.nih.gov/pubmed/23578194 http://dx.doi.org/10.1186/1471-230X-13-63 |
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author | Ardengh, José Celso Lopes, César Vivian Kemp, Rafael Venco, Filadélfio de Lima-Filho, Eder Rios dos Santos, José Sebastião |
author_facet | Ardengh, José Celso Lopes, César Vivian Kemp, Rafael Venco, Filadélfio de Lima-Filho, Eder Rios dos Santos, José Sebastião |
author_sort | Ardengh, José Celso |
collection | PubMed |
description | BACKGROUND: Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas. METHODS: In a retrospective review, patients with pancreatic solid tumours and history of previous extrapancreatic cancer underwent EUS-FNA from January/1997 to December/2010. Most patients were followed-up until death and some of them were still alive at the end of the study. The performance of EUS-FNA for diagnosis of pancreatic metastases was analyzed. Symptoms, time frame between primary tumour diagnosis and the finding of metastases, and survival after diagnosis were also analyzed. RESULTS: 37 patients underwent EUS-FNA for probable pancreas metastases. Most cases (65%) presented with symptoms, especially upper abdominal pain (46%). Median time between detection of the first tumour and the finding of pancreatic metastases was 36 months. Metastases were confirmed in 32 (1.6%) cases, 30 of them by EUS-FNA, and 2 by surgery. Other 5 cases were non-metastatic. Most metastases were from lymphoma, colon, lung, and kidney. Twelve (32%) patients were submitted to surgery. Median survival after diagnosis of pancreatic metastases was 9 months, with no difference of survival between surgical and non-surgical cases. Sensitivity, specificity, positive and negative predictive values, and accuracy of EUS-FNA with histology analysis of the specimens for diagnosis of pancreatic metastases were, respectively, 93.8%, 60%, 93.8%, 60% and 89%. CONCLUSION: EUS-FNA with histology of the specimens is a sensitive and accurate method for definitive diagnosis of metastatic disease in patients with a previous history of extrapancreatic malignancies. |
format | Online Article Text |
id | pubmed-3651366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36513662013-05-11 Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases Ardengh, José Celso Lopes, César Vivian Kemp, Rafael Venco, Filadélfio de Lima-Filho, Eder Rios dos Santos, José Sebastião BMC Gastroenterol Research Article BACKGROUND: Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosis of metastases to the pancreas. METHODS: In a retrospective review, patients with pancreatic solid tumours and history of previous extrapancreatic cancer underwent EUS-FNA from January/1997 to December/2010. Most patients were followed-up until death and some of them were still alive at the end of the study. The performance of EUS-FNA for diagnosis of pancreatic metastases was analyzed. Symptoms, time frame between primary tumour diagnosis and the finding of metastases, and survival after diagnosis were also analyzed. RESULTS: 37 patients underwent EUS-FNA for probable pancreas metastases. Most cases (65%) presented with symptoms, especially upper abdominal pain (46%). Median time between detection of the first tumour and the finding of pancreatic metastases was 36 months. Metastases were confirmed in 32 (1.6%) cases, 30 of them by EUS-FNA, and 2 by surgery. Other 5 cases were non-metastatic. Most metastases were from lymphoma, colon, lung, and kidney. Twelve (32%) patients were submitted to surgery. Median survival after diagnosis of pancreatic metastases was 9 months, with no difference of survival between surgical and non-surgical cases. Sensitivity, specificity, positive and negative predictive values, and accuracy of EUS-FNA with histology analysis of the specimens for diagnosis of pancreatic metastases were, respectively, 93.8%, 60%, 93.8%, 60% and 89%. CONCLUSION: EUS-FNA with histology of the specimens is a sensitive and accurate method for definitive diagnosis of metastatic disease in patients with a previous history of extrapancreatic malignancies. BioMed Central 2013-04-11 /pmc/articles/PMC3651366/ /pubmed/23578194 http://dx.doi.org/10.1186/1471-230X-13-63 Text en Copyright © 2013 Ardengh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ardengh, José Celso Lopes, César Vivian Kemp, Rafael Venco, Filadélfio de Lima-Filho, Eder Rios dos Santos, José Sebastião Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
title | Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
title_full | Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
title_fullStr | Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
title_full_unstemmed | Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
title_short | Accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
title_sort | accuracy of endoscopic ultrasound-guided fine-needle aspiration in the suspicion of pancreatic metastases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651366/ https://www.ncbi.nlm.nih.gov/pubmed/23578194 http://dx.doi.org/10.1186/1471-230X-13-63 |
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