IGF1R levels in the brain negatively correlate with longevity in 16 rodent species

The insulin/insulin-like growth factor signaling (IIS) pathway is a major conserved regulator of aging. Nematode, fruit fly and mouse mutants with reduced IIS signaling exhibit extended lifespan. These mutants are often dwarfs leading to the idea that small body mass correlates with longevity within...

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Detalles Bibliográficos
Autores principales: Azpurua, Jorge, Yang, Jiang-Nan, Van Meter, Michael, Liu, Zhengshan, Kim, Julie, Lobo Ladd, Aliny AB, Coppi, Antonio Augusto, Gorbunova, Vera, Seluanov, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651522/
https://www.ncbi.nlm.nih.gov/pubmed/23651613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651522/
https://www.ncbi.nlm.nih.gov/pubmed/23651613

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