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Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers
We investigated the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for restaging of treated uterine cervix squamous cell cancer with tumor maker elevation that was not explained by other conventional evaluation. We enrolled 32 cases who underwe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chonnam National University Medical School
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651982/ https://www.ncbi.nlm.nih.gov/pubmed/23678473 http://dx.doi.org/10.4068/cmj.2013.49.1.20 |
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author | Chong, Ari Ha, Jung-Min Jeong, Shin Young Song, Ho-Chun Min, Jung Joon Bom, Hee-Seung Choi, Ho-Sun |
author_facet | Chong, Ari Ha, Jung-Min Jeong, Shin Young Song, Ho-Chun Min, Jung Joon Bom, Hee-Seung Choi, Ho-Sun |
author_sort | Chong, Ari |
collection | PubMed |
description | We investigated the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for restaging of treated uterine cervix squamous cell cancer with tumor maker elevation that was not explained by other conventional evaluation. We enrolled 32 cases who underwent PET/CT for the restaging of treated cervical cancer with tumor marker elevation that was not explained by recent conventional evaluation. All enrolled cases had squamous cell carcinoma. Increased tumor markers included squamous cell carcinoma antigen (SCC Ag) and carcinoembryonic antigen (CEA). PET/CT findings were determined by pathologic confirmation or clinical follow-up. We compared PET/CT accuracy and clinical parameters including normalization of tumor markers in both the SCC Ag elevation group and the CEA elevation group. The sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT in detecting recurrence were 100%, 83.3%, 82.4%, and 100%, respectively. Accuracy was significantly different between the SCC Ag elevation group and the CEA elevation group (p=0.0169). PET/CT with SCC Ag elevation was more accurate (100%) than PET/CT with CEA elevation (66.7%). Normalization of tumor markers was observed more often in the SCC Ag elevation group than in the CEA elevation group (p=0.0429). PET/CT showed high negative predictive value and sensitivity in the restaging of cervical cancer with unexplained tumor marker elevation. PET/CT was more accurate in patients with SCC Ag elevation than in those with CEA elevation. |
format | Online Article Text |
id | pubmed-3651982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Chonnam National University Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-36519822013-05-15 Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers Chong, Ari Ha, Jung-Min Jeong, Shin Young Song, Ho-Chun Min, Jung Joon Bom, Hee-Seung Choi, Ho-Sun Chonnam Med J Original Article We investigated the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for restaging of treated uterine cervix squamous cell cancer with tumor maker elevation that was not explained by other conventional evaluation. We enrolled 32 cases who underwent PET/CT for the restaging of treated cervical cancer with tumor marker elevation that was not explained by recent conventional evaluation. All enrolled cases had squamous cell carcinoma. Increased tumor markers included squamous cell carcinoma antigen (SCC Ag) and carcinoembryonic antigen (CEA). PET/CT findings were determined by pathologic confirmation or clinical follow-up. We compared PET/CT accuracy and clinical parameters including normalization of tumor markers in both the SCC Ag elevation group and the CEA elevation group. The sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT in detecting recurrence were 100%, 83.3%, 82.4%, and 100%, respectively. Accuracy was significantly different between the SCC Ag elevation group and the CEA elevation group (p=0.0169). PET/CT with SCC Ag elevation was more accurate (100%) than PET/CT with CEA elevation (66.7%). Normalization of tumor markers was observed more often in the SCC Ag elevation group than in the CEA elevation group (p=0.0429). PET/CT showed high negative predictive value and sensitivity in the restaging of cervical cancer with unexplained tumor marker elevation. PET/CT was more accurate in patients with SCC Ag elevation than in those with CEA elevation. Chonnam National University Medical School 2013-04 2013-04-25 /pmc/articles/PMC3651982/ /pubmed/23678473 http://dx.doi.org/10.4068/cmj.2013.49.1.20 Text en © Chonnam Medical Journal, 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chong, Ari Ha, Jung-Min Jeong, Shin Young Song, Ho-Chun Min, Jung Joon Bom, Hee-Seung Choi, Ho-Sun Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers |
title | Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers |
title_full | Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers |
title_fullStr | Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers |
title_full_unstemmed | Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers |
title_short | Clinical Usefulness of (18)F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers |
title_sort | clinical usefulness of (18)f-fdg pet/ct in the detection of early recurrence in treated cervical cancer patients with unexplained elevation of serum tumor markers |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651982/ https://www.ncbi.nlm.nih.gov/pubmed/23678473 http://dx.doi.org/10.4068/cmj.2013.49.1.20 |
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