A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125

Distal epithelioid sarcoma is a rare and slowly growing tumor that usually develops in the upper extremities of young adults. Neoplastic cells have both spindle and epithelioid appearance and are characterized by the loss of the nuclear protein SMARCB1/INI1. We present the case of a distal epithelio...

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Autores principales: Karagkounis, George, Argyrakos, Theodore, Charkiolakis, G., Castana, O., Rontogianni, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652053/
https://www.ncbi.nlm.nih.gov/pubmed/23691400
http://dx.doi.org/10.1155/2013/312786
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author Karagkounis, George
Argyrakos, Theodore
Charkiolakis, G.
Castana, O.
Rontogianni, D.
author_facet Karagkounis, George
Argyrakos, Theodore
Charkiolakis, G.
Castana, O.
Rontogianni, D.
author_sort Karagkounis, George
collection PubMed
description Distal epithelioid sarcoma is a rare and slowly growing tumor that usually develops in the upper extremities of young adults. Neoplastic cells have both spindle and epithelioid appearance and are characterized by the loss of the nuclear protein SMARCB1/INI1. We present the case of a distal epithelioid sarcoma arising in the thumb of a 14-year-old girl, which immunohistochemically was characterized by the loss of SMARCB1/INI1 protein as well as the expression of podoplanin (D2-40), TLE1, Glut1, and Ca 125; plus, we highlight the differential diagnosis of epithelioid sarcoma from its histological mimics.
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spelling pubmed-36520532013-05-20 A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125 Karagkounis, George Argyrakos, Theodore Charkiolakis, G. Castana, O. Rontogianni, D. Case Rep Pathol Case Report Distal epithelioid sarcoma is a rare and slowly growing tumor that usually develops in the upper extremities of young adults. Neoplastic cells have both spindle and epithelioid appearance and are characterized by the loss of the nuclear protein SMARCB1/INI1. We present the case of a distal epithelioid sarcoma arising in the thumb of a 14-year-old girl, which immunohistochemically was characterized by the loss of SMARCB1/INI1 protein as well as the expression of podoplanin (D2-40), TLE1, Glut1, and Ca 125; plus, we highlight the differential diagnosis of epithelioid sarcoma from its histological mimics. Hindawi Publishing Corporation 2013 2013-04-18 /pmc/articles/PMC3652053/ /pubmed/23691400 http://dx.doi.org/10.1155/2013/312786 Text en Copyright © 2013 George Karagkounis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Karagkounis, George
Argyrakos, Theodore
Charkiolakis, G.
Castana, O.
Rontogianni, D.
A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125
title A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125
title_full A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125
title_fullStr A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125
title_full_unstemmed A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125
title_short A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125
title_sort case of distal epithelioid sarcoma of the thumb expressing podoplanin, tle1 and ca 125
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652053/
https://www.ncbi.nlm.nih.gov/pubmed/23691400
http://dx.doi.org/10.1155/2013/312786
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