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Microglial Dysregulation in Psychiatric Disease
Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652125/ https://www.ncbi.nlm.nih.gov/pubmed/23690824 http://dx.doi.org/10.1155/2013/608654 |
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author | Frick, Luciana Romina Williams, Kyle Pittenger, Christopher |
author_facet | Frick, Luciana Romina Williams, Kyle Pittenger, Christopher |
author_sort | Frick, Luciana Romina |
collection | PubMed |
description | Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy. |
format | Online Article Text |
id | pubmed-3652125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36521252013-05-20 Microglial Dysregulation in Psychiatric Disease Frick, Luciana Romina Williams, Kyle Pittenger, Christopher Clin Dev Immunol Review Article Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy. Hindawi Publishing Corporation 2013 2013-04-18 /pmc/articles/PMC3652125/ /pubmed/23690824 http://dx.doi.org/10.1155/2013/608654 Text en Copyright © 2013 Luciana Romina Frick et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Frick, Luciana Romina Williams, Kyle Pittenger, Christopher Microglial Dysregulation in Psychiatric Disease |
title | Microglial Dysregulation in Psychiatric Disease |
title_full | Microglial Dysregulation in Psychiatric Disease |
title_fullStr | Microglial Dysregulation in Psychiatric Disease |
title_full_unstemmed | Microglial Dysregulation in Psychiatric Disease |
title_short | Microglial Dysregulation in Psychiatric Disease |
title_sort | microglial dysregulation in psychiatric disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652125/ https://www.ncbi.nlm.nih.gov/pubmed/23690824 http://dx.doi.org/10.1155/2013/608654 |
work_keys_str_mv | AT fricklucianaromina microglialdysregulationinpsychiatricdisease AT williamskyle microglialdysregulationinpsychiatricdisease AT pittengerchristopher microglialdysregulationinpsychiatricdisease |