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Microglial Dysregulation in Psychiatric Disease

Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including...

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Detalles Bibliográficos
Autores principales: Frick, Luciana Romina, Williams, Kyle, Pittenger, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652125/
https://www.ncbi.nlm.nih.gov/pubmed/23690824
http://dx.doi.org/10.1155/2013/608654
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author Frick, Luciana Romina
Williams, Kyle
Pittenger, Christopher
author_facet Frick, Luciana Romina
Williams, Kyle
Pittenger, Christopher
author_sort Frick, Luciana Romina
collection PubMed
description Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy.
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spelling pubmed-36521252013-05-20 Microglial Dysregulation in Psychiatric Disease Frick, Luciana Romina Williams, Kyle Pittenger, Christopher Clin Dev Immunol Review Article Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy. Hindawi Publishing Corporation 2013 2013-04-18 /pmc/articles/PMC3652125/ /pubmed/23690824 http://dx.doi.org/10.1155/2013/608654 Text en Copyright © 2013 Luciana Romina Frick et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Frick, Luciana Romina
Williams, Kyle
Pittenger, Christopher
Microglial Dysregulation in Psychiatric Disease
title Microglial Dysregulation in Psychiatric Disease
title_full Microglial Dysregulation in Psychiatric Disease
title_fullStr Microglial Dysregulation in Psychiatric Disease
title_full_unstemmed Microglial Dysregulation in Psychiatric Disease
title_short Microglial Dysregulation in Psychiatric Disease
title_sort microglial dysregulation in psychiatric disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652125/
https://www.ncbi.nlm.nih.gov/pubmed/23690824
http://dx.doi.org/10.1155/2013/608654
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