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Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last...

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Autores principales: Margaritopoulos, George A., Tsitoura, Eliza, Tzanakis, Nikos, Spandidos, Demetrios A., Siafakas, Nikos M., Sourvinos, George, Antoniou, Katerina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652133/
https://www.ncbi.nlm.nih.gov/pubmed/23691501
http://dx.doi.org/10.1155/2013/420497
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author Margaritopoulos, George A.
Tsitoura, Eliza
Tzanakis, Nikos
Spandidos, Demetrios A.
Siafakas, Nikos M.
Sourvinos, George
Antoniou, Katerina M.
author_facet Margaritopoulos, George A.
Tsitoura, Eliza
Tzanakis, Nikos
Spandidos, Demetrios A.
Siafakas, Nikos M.
Sourvinos, George
Antoniou, Katerina M.
author_sort Margaritopoulos, George A.
collection PubMed
description Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3–5 years is still 50%. Autophagy, a highly conserved homeostatic mechanism necessary for cell survival, has been recently implicated in the pathogenesis of pulmonary disorders. In this paper we aim to highlight some key issues regarding the process of autophagy and its possible association with the pathogenesis of idiopathic pulmonary fibrosis.
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spelling pubmed-36521332013-05-20 Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis Margaritopoulos, George A. Tsitoura, Eliza Tzanakis, Nikos Spandidos, Demetrios A. Siafakas, Nikos M. Sourvinos, George Antoniou, Katerina M. Biomed Res Int Review Article Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3–5 years is still 50%. Autophagy, a highly conserved homeostatic mechanism necessary for cell survival, has been recently implicated in the pathogenesis of pulmonary disorders. In this paper we aim to highlight some key issues regarding the process of autophagy and its possible association with the pathogenesis of idiopathic pulmonary fibrosis. Hindawi Publishing Corporation 2013 2013-04-10 /pmc/articles/PMC3652133/ /pubmed/23691501 http://dx.doi.org/10.1155/2013/420497 Text en Copyright © 2013 George A. Margaritopoulos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Margaritopoulos, George A.
Tsitoura, Eliza
Tzanakis, Nikos
Spandidos, Demetrios A.
Siafakas, Nikos M.
Sourvinos, George
Antoniou, Katerina M.
Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
title Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
title_full Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
title_fullStr Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
title_full_unstemmed Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
title_short Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
title_sort self-eating: friend or foe? the emerging role of autophagy in idiopathic pulmonary fibrosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652133/
https://www.ncbi.nlm.nih.gov/pubmed/23691501
http://dx.doi.org/10.1155/2013/420497
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