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Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652133/ https://www.ncbi.nlm.nih.gov/pubmed/23691501 http://dx.doi.org/10.1155/2013/420497 |
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author | Margaritopoulos, George A. Tsitoura, Eliza Tzanakis, Nikos Spandidos, Demetrios A. Siafakas, Nikos M. Sourvinos, George Antoniou, Katerina M. |
author_facet | Margaritopoulos, George A. Tsitoura, Eliza Tzanakis, Nikos Spandidos, Demetrios A. Siafakas, Nikos M. Sourvinos, George Antoniou, Katerina M. |
author_sort | Margaritopoulos, George A. |
collection | PubMed |
description | Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3–5 years is still 50%. Autophagy, a highly conserved homeostatic mechanism necessary for cell survival, has been recently implicated in the pathogenesis of pulmonary disorders. In this paper we aim to highlight some key issues regarding the process of autophagy and its possible association with the pathogenesis of idiopathic pulmonary fibrosis. |
format | Online Article Text |
id | pubmed-3652133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36521332013-05-20 Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis Margaritopoulos, George A. Tsitoura, Eliza Tzanakis, Nikos Spandidos, Demetrios A. Siafakas, Nikos M. Sourvinos, George Antoniou, Katerina M. Biomed Res Int Review Article Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonias. Despite an exponential increase in our understanding of potentially important mediators and mechanisms, the pathogenesis remains elusive, and little therapeutic progress has been made in the last few years. Mortality in 3–5 years is still 50%. Autophagy, a highly conserved homeostatic mechanism necessary for cell survival, has been recently implicated in the pathogenesis of pulmonary disorders. In this paper we aim to highlight some key issues regarding the process of autophagy and its possible association with the pathogenesis of idiopathic pulmonary fibrosis. Hindawi Publishing Corporation 2013 2013-04-10 /pmc/articles/PMC3652133/ /pubmed/23691501 http://dx.doi.org/10.1155/2013/420497 Text en Copyright © 2013 George A. Margaritopoulos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Margaritopoulos, George A. Tsitoura, Eliza Tzanakis, Nikos Spandidos, Demetrios A. Siafakas, Nikos M. Sourvinos, George Antoniou, Katerina M. Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis |
title | Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis |
title_full | Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis |
title_fullStr | Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis |
title_full_unstemmed | Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis |
title_short | Self-Eating: Friend or Foe? The Emerging Role of Autophagy in Idiopathic Pulmonary Fibrosis |
title_sort | self-eating: friend or foe? the emerging role of autophagy in idiopathic pulmonary fibrosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652133/ https://www.ncbi.nlm.nih.gov/pubmed/23691501 http://dx.doi.org/10.1155/2013/420497 |
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