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Merkel Cell Carcinoma: The Past, the Present, and the Future
Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652192/ https://www.ncbi.nlm.nih.gov/pubmed/23691324 http://dx.doi.org/10.1155/2013/929364 |
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author | Erovic, Inamaria Erovic, Boban M. |
author_facet | Erovic, Inamaria Erovic, Boban M. |
author_sort | Erovic, Inamaria |
collection | PubMed |
description | Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease. |
format | Online Article Text |
id | pubmed-3652192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36521922013-05-20 Merkel Cell Carcinoma: The Past, the Present, and the Future Erovic, Inamaria Erovic, Boban M. J Skin Cancer Review Article Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease. Hindawi Publishing Corporation 2013 2013-04-16 /pmc/articles/PMC3652192/ /pubmed/23691324 http://dx.doi.org/10.1155/2013/929364 Text en Copyright © 2013 I. Erovic and B. M. Erovic. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Erovic, Inamaria Erovic, Boban M. Merkel Cell Carcinoma: The Past, the Present, and the Future |
title | Merkel Cell Carcinoma: The Past, the Present, and the Future |
title_full | Merkel Cell Carcinoma: The Past, the Present, and the Future |
title_fullStr | Merkel Cell Carcinoma: The Past, the Present, and the Future |
title_full_unstemmed | Merkel Cell Carcinoma: The Past, the Present, and the Future |
title_short | Merkel Cell Carcinoma: The Past, the Present, and the Future |
title_sort | merkel cell carcinoma: the past, the present, and the future |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652192/ https://www.ncbi.nlm.nih.gov/pubmed/23691324 http://dx.doi.org/10.1155/2013/929364 |
work_keys_str_mv | AT erovicinamaria merkelcellcarcinomathepastthepresentandthefuture AT erovicbobanm merkelcellcarcinomathepastthepresentandthefuture |