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Merkel Cell Carcinoma: The Past, the Present, and the Future

Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description...

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Detalles Bibliográficos
Autores principales: Erovic, Inamaria, Erovic, Boban M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652192/
https://www.ncbi.nlm.nih.gov/pubmed/23691324
http://dx.doi.org/10.1155/2013/929364
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author Erovic, Inamaria
Erovic, Boban M.
author_facet Erovic, Inamaria
Erovic, Boban M.
author_sort Erovic, Inamaria
collection PubMed
description Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease.
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spelling pubmed-36521922013-05-20 Merkel Cell Carcinoma: The Past, the Present, and the Future Erovic, Inamaria Erovic, Boban M. J Skin Cancer Review Article Since the first description of the Merkel cell carcinoma by Cyril Toker in 1972, the number of studies has significantly increased over the last 4 decades. In this review, we will illustrate the historical background of the Merkel cell carcinoma beginning with the 19th century, the first description of the Merkel cell to the finding of the CK20 as a highly specific diagnostic marker and finally to the recently detected Merkel cell polyomavirus (MCPyV). Moreover, we will highlight the beginning of adjuvant therapeutic regimens with radiotherapy and chemotherapy and discuss the diagnostic work-up including imaging and histology of patients with Merkel cell carcinoma. Another very rapidly growing and interesting field of research is the development of patients' specific and tailored targeted therapy, in particular in patients with distant metastatic disease. Hindawi Publishing Corporation 2013 2013-04-16 /pmc/articles/PMC3652192/ /pubmed/23691324 http://dx.doi.org/10.1155/2013/929364 Text en Copyright © 2013 I. Erovic and B. M. Erovic. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Erovic, Inamaria
Erovic, Boban M.
Merkel Cell Carcinoma: The Past, the Present, and the Future
title Merkel Cell Carcinoma: The Past, the Present, and the Future
title_full Merkel Cell Carcinoma: The Past, the Present, and the Future
title_fullStr Merkel Cell Carcinoma: The Past, the Present, and the Future
title_full_unstemmed Merkel Cell Carcinoma: The Past, the Present, and the Future
title_short Merkel Cell Carcinoma: The Past, the Present, and the Future
title_sort merkel cell carcinoma: the past, the present, and the future
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652192/
https://www.ncbi.nlm.nih.gov/pubmed/23691324
http://dx.doi.org/10.1155/2013/929364
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