Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy

Parkinson's disease (PD) is associated with loss of dopaminergic signalling, and affects not just movement, but also vision. As both mammalian and fly visual systems contain dopaminergic neurons, we investigated the effect of LRRK2 mutations (the most common cause of inherited PD) on Drosophila...

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Detalles Bibliográficos
Autores principales: Hindle, Samantha, Afsari, Farinaz, Stark, Meg, Middleton, C. Adam, Evans, Gareth J.O., Sweeney, Sean T., Elliott, Christopher J.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652415/
https://www.ncbi.nlm.nih.gov/pubmed/23396536
http://dx.doi.org/10.1093/hmg/ddt061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652415/
https://www.ncbi.nlm.nih.gov/pubmed/23396536
http://dx.doi.org/10.1093/hmg/ddt061

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