Adaptive changes in the neuronal proteome: mitochondrial energy production, endoplasmic reticulum stress, and ribosomal dysfunction in the cellular response to metabolic stress

Impaired energy metabolism in neurons is integral to a range of neurodegenerative diseases, from Alzheimer's disease to stroke. To investigate the complex molecular changes underpinning cellular adaptation to metabolic stress, we have defined the proteomic response of the SH-SY5Y human neurobla...

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Detalles Bibliográficos
Autores principales: Herrmann, Abigail G, Deighton, Ruth F, Le Bihan, Thierry, McCulloch, Mailis C, Searcy, James L, Kerr, Lorraine E, McCulloch, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652695/
https://www.ncbi.nlm.nih.gov/pubmed/23321784
http://dx.doi.org/10.1038/jcbfm.2012.204

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