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CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome

BACKGROUND: Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early in the disease. Specific biomarkers for this process are of great interest. OBJECTIVE: To study if cerebrospinal fluid (CSF) biomarkers for axonal damage reflect and predict disease pro...

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Autores principales: Khalil, M, Enzinger, C, Langkammer, C, Ropele, S, Mader, A, Trentini, A, Vane, MLG, Wallner-Blazek, M, Bachmaier, G, Archelos, J-J, Koel-Simmelink, MJA, Blankenstein, MA, Fuchs, S, Fazekas, F, Teunissen, CE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652709/
https://www.ncbi.nlm.nih.gov/pubmed/22917689
http://dx.doi.org/10.1177/1352458512458010
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author Khalil, M
Enzinger, C
Langkammer, C
Ropele, S
Mader, A
Trentini, A
Vane, MLG
Wallner-Blazek, M
Bachmaier, G
Archelos, J-J
Koel-Simmelink, MJA
Blankenstein, MA
Fuchs, S
Fazekas, F
Teunissen, CE
author_facet Khalil, M
Enzinger, C
Langkammer, C
Ropele, S
Mader, A
Trentini, A
Vane, MLG
Wallner-Blazek, M
Bachmaier, G
Archelos, J-J
Koel-Simmelink, MJA
Blankenstein, MA
Fuchs, S
Fazekas, F
Teunissen, CE
author_sort Khalil, M
collection PubMed
description BACKGROUND: Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early in the disease. Specific biomarkers for this process are of great interest. OBJECTIVE: To study if cerebrospinal fluid (CSF) biomarkers for axonal damage reflect and predict disease progression already in the earliest stages of the disease, that is, in clinically isolated syndrome (CIS). METHODS: We assessed CSF levels of neurofilament heavy (NFH), neurofilament light (NFL) and N-acetylaspartate (NAA) in 67 patients with CIS and 18 controls with neuropsychiatric diseases of non-inflammatory aetiology (NC). Patients with CIS underwent baseline magnetic resonance imaging (MRI) at 3T, and a follow-up MRI after 1 year was obtained in 28 of them. RESULTS: Compared with NC, patients with CIS had higher NFH (p=0.05) and NFL (p<0.001) levels. No significant group differences were found for NAA. Patients’ NFH levels correlated with physical disability (r=0.304, p<0.05) and with change in brain volume over 1 year of follow-up (r=-0.518, p<0.01) but not with change in T2 lesion load. CONCLUSION: Our results confirm increased neurofilament levels already in CIS being related to the level of physical disability. The association of NFH levels with brain volume but not lesion volume changes supports the association of these markers with axonal damage.
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spelling pubmed-36527092013-06-03 CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome Khalil, M Enzinger, C Langkammer, C Ropele, S Mader, A Trentini, A Vane, MLG Wallner-Blazek, M Bachmaier, G Archelos, J-J Koel-Simmelink, MJA Blankenstein, MA Fuchs, S Fazekas, F Teunissen, CE Mult Scler Research Papers BACKGROUND: Axonal damage is considered a major cause of disability in multiple sclerosis (MS) and may start early in the disease. Specific biomarkers for this process are of great interest. OBJECTIVE: To study if cerebrospinal fluid (CSF) biomarkers for axonal damage reflect and predict disease progression already in the earliest stages of the disease, that is, in clinically isolated syndrome (CIS). METHODS: We assessed CSF levels of neurofilament heavy (NFH), neurofilament light (NFL) and N-acetylaspartate (NAA) in 67 patients with CIS and 18 controls with neuropsychiatric diseases of non-inflammatory aetiology (NC). Patients with CIS underwent baseline magnetic resonance imaging (MRI) at 3T, and a follow-up MRI after 1 year was obtained in 28 of them. RESULTS: Compared with NC, patients with CIS had higher NFH (p=0.05) and NFL (p<0.001) levels. No significant group differences were found for NAA. Patients’ NFH levels correlated with physical disability (r=0.304, p<0.05) and with change in brain volume over 1 year of follow-up (r=-0.518, p<0.01) but not with change in T2 lesion load. CONCLUSION: Our results confirm increased neurofilament levels already in CIS being related to the level of physical disability. The association of NFH levels with brain volume but not lesion volume changes supports the association of these markers with axonal damage. SAGE Publications 2013-04 /pmc/articles/PMC3652709/ /pubmed/22917689 http://dx.doi.org/10.1177/1352458512458010 Text en © The Author(s) 2012 http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Papers
Khalil, M
Enzinger, C
Langkammer, C
Ropele, S
Mader, A
Trentini, A
Vane, MLG
Wallner-Blazek, M
Bachmaier, G
Archelos, J-J
Koel-Simmelink, MJA
Blankenstein, MA
Fuchs, S
Fazekas, F
Teunissen, CE
CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
title CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
title_full CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
title_fullStr CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
title_full_unstemmed CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
title_short CSF neurofilament and N-acetylaspartate related brain changes in clinically isolated syndrome
title_sort csf neurofilament and n-acetylaspartate related brain changes in clinically isolated syndrome
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652709/
https://www.ncbi.nlm.nih.gov/pubmed/22917689
http://dx.doi.org/10.1177/1352458512458010
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