Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

Elevated LDL-cholesterol (LDLc) levels are a major risk factor for cardiovascular disease and atherosclerosis. LDLc is cleared from circulation by the LDL receptor (LDLR). Proprotein convertase subtilisin/kexin 9 (PCSK9) enhances the degradation of the LDLR in endosomes/lysosomes, resulting in incre...

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Detalles Bibliográficos
Autores principales: Canuel, Maryssa, Sun, Xiaowei, Asselin, Marie-Claude, Paramithiotis, Eustache, Prat, Annik, Seidah, Nabil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652815/
https://www.ncbi.nlm.nih.gov/pubmed/23675525
http://dx.doi.org/10.1371/journal.pone.0064145

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