Regulation of IDO Activity by Oxygen Supply: Inhibitory Effects on Antimicrobial and Immunoregulatory Functions

Tryptophan is an essential amino acid for human beings as well as for some microorganisms. In human cells the interferon-γ (IFN-γ) inducible enzyme indoleamine 2,3-dioxygenase (IDO) reduces local tryptophan levels and is therefore able to mediate broad-spectrum effector functions: IDO activity restr...

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Detalles Bibliográficos
Autores principales: Schmidt, Silvia K., Ebel, Sebastian, Keil, Eric, Woite, Claudia, Ernst, Joachim F., Benzin, Anika E., Rupp, Jan, Däubener, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652816/
https://www.ncbi.nlm.nih.gov/pubmed/23675474
http://dx.doi.org/10.1371/journal.pone.0063301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652816/
https://www.ncbi.nlm.nih.gov/pubmed/23675474
http://dx.doi.org/10.1371/journal.pone.0063301

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