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Regulation of IDO Activity by Oxygen Supply: Inhibitory Effects on Antimicrobial and Immunoregulatory Functions

Tryptophan is an essential amino acid for human beings as well as for some microorganisms. In human cells the interferon-γ (IFN-γ) inducible enzyme indoleamine 2,3-dioxygenase (IDO) reduces local tryptophan levels and is therefore able to mediate broad-spectrum effector functions: IDO activity restr...

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Detalles Bibliográficos
Autores principales:	Schmidt, Silvia K., Ebel, Sebastian, Keil, Eric, Woite, Claudia, Ernst, Joachim F., Benzin, Anika E., Rupp, Jan, Däubener, Walter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652816/ https://www.ncbi.nlm.nih.gov/pubmed/23675474 http://dx.doi.org/10.1371/journal.pone.0063301

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