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A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens
Distinguishing between clastogens and aneugens is vital in cancer risk assessment because the default assumption is that clastogens and aneugens have linear and non-linear dose-response curves, respectively. Any observed non-linearity must be supported by mode of action (MOA) analyses where biologic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652818/ https://www.ncbi.nlm.nih.gov/pubmed/23675539 http://dx.doi.org/10.1371/journal.pone.0064532 |