Targeting Caspase-3 as Dual Therapeutic Benefits by RNAi Facilitating Brain-Targeted Nanoparticles in a Rat Model of Parkinson’s Disease

The activation of caspase-3 is an important hallmark in Parkinson’s disease. It could induce neuron death by apoptosis and microglia activation by inflammation. As a result, inhibition the activation of caspase-3 would exert synergistic dual effect in brain in order to prevent the progress of Parkin...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Guo, Yubo, An, Sai, Kuang, Yuyang, He, Xi, Ma, Haojun, Li, Jianfeng, Lv, Jing, Zhang, Ning, Jiang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652845/
https://www.ncbi.nlm.nih.gov/pubmed/23675438
http://dx.doi.org/10.1371/journal.pone.0062905

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