A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties

A growing number of DNA transacting proteins is found in the nucleus and in mitochondria, including the DNA repair and replication protein Flap endonuclease 1, FEN1. Here we show a truncated FEN1 isoform is generated by alternative translation initiation, exposing a mitochondrial targeting signal. T...

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Detalles Bibliográficos
Autores principales: Kazak, Lawrence, Reyes, Aurelio, He, Jiuya, Wood, Stuart R., Brea-Calvo, Gloria, Holen, Torgeir T., Holt, Ian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652857/
https://www.ncbi.nlm.nih.gov/pubmed/23675412
http://dx.doi.org/10.1371/journal.pone.0062340

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