Cargando…
Transient Global Amnesia and Neurological Events: The Framingham Heart Study
Background/objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurolo...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653124/ https://www.ncbi.nlm.nih.gov/pubmed/23675365 http://dx.doi.org/10.3389/fneur.2013.00047 |
_version_ | 1782269390358577152 |
---|---|
author | Romero, José Rafael Mercado, Melissa Beiser, Alexa S. Pikula, Aleksandra Seshadri, Sudha Kelly-Hayes, Margaret Wolf, Philip A. Kase, Carlos S. |
author_facet | Romero, José Rafael Mercado, Melissa Beiser, Alexa S. Pikula, Aleksandra Seshadri, Sudha Kelly-Hayes, Margaret Wolf, Philip A. Kase, Carlos S. |
author_sort | Romero, José Rafael |
collection | PubMed |
description | Background/objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurological events. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI) indices of subclinical ischemia and neurological events in a community-based sample. Design/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. Participants: Framingham Heart Study (FHS) original and offspring cohort participants were included. Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Few incident stroke/transient ischemic attacks (TIA) (one event among the cases and four in controls) or subsequent seizures occurred in either group. Head CT during the acute event (n = 11) and brain MRI (n = 7) were negative for acute abnormalities. Electroencephalograms (EEG) (n = 5) were negative for epileptiform activity. Extracranial vascular studies were negative for significant stenosis in all cases. Conclusion: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. However, our study is limited by small sample size and power, and larger studies are required to exclude an association. |
format | Online Article Text |
id | pubmed-3653124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36531242013-05-14 Transient Global Amnesia and Neurological Events: The Framingham Heart Study Romero, José Rafael Mercado, Melissa Beiser, Alexa S. Pikula, Aleksandra Seshadri, Sudha Kelly-Hayes, Margaret Wolf, Philip A. Kase, Carlos S. Front Neurol Neuroscience Background/objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurological events. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI) indices of subclinical ischemia and neurological events in a community-based sample. Design/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. Participants: Framingham Heart Study (FHS) original and offspring cohort participants were included. Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Few incident stroke/transient ischemic attacks (TIA) (one event among the cases and four in controls) or subsequent seizures occurred in either group. Head CT during the acute event (n = 11) and brain MRI (n = 7) were negative for acute abnormalities. Electroencephalograms (EEG) (n = 5) were negative for epileptiform activity. Extracranial vascular studies were negative for significant stenosis in all cases. Conclusion: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. However, our study is limited by small sample size and power, and larger studies are required to exclude an association. Frontiers Media S.A. 2013-05-14 /pmc/articles/PMC3653124/ /pubmed/23675365 http://dx.doi.org/10.3389/fneur.2013.00047 Text en Copyright © 2013 Romero, Mercado, Beiser, Pikula, Seshadri, Kelly-Hayes, Wolf and Kase. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience Romero, José Rafael Mercado, Melissa Beiser, Alexa S. Pikula, Aleksandra Seshadri, Sudha Kelly-Hayes, Margaret Wolf, Philip A. Kase, Carlos S. Transient Global Amnesia and Neurological Events: The Framingham Heart Study |
title | Transient Global Amnesia and Neurological Events: The Framingham Heart Study |
title_full | Transient Global Amnesia and Neurological Events: The Framingham Heart Study |
title_fullStr | Transient Global Amnesia and Neurological Events: The Framingham Heart Study |
title_full_unstemmed | Transient Global Amnesia and Neurological Events: The Framingham Heart Study |
title_short | Transient Global Amnesia and Neurological Events: The Framingham Heart Study |
title_sort | transient global amnesia and neurological events: the framingham heart study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653124/ https://www.ncbi.nlm.nih.gov/pubmed/23675365 http://dx.doi.org/10.3389/fneur.2013.00047 |
work_keys_str_mv | AT romerojoserafael transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT mercadomelissa transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT beiseralexas transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT pikulaaleksandra transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT seshadrisudha transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT kellyhayesmargaret transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT wolfphilipa transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT kasecarloss transientglobalamnesiaandneurologicaleventstheframinghamheartstudy |