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Route to destruction: Autophagosomes SNARE lysosomes
Autophagy allows cells to encapsulate parts of their cytosol into unique double-membrane structures. These autophagosomes mature to fuse with lysosomes and deliver the enclosed contents for degradation. Three recent papers, including one by Takáts et al. (2013. J. Cell Biol. http://dx.doi.org/10.108...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653355/ https://www.ncbi.nlm.nih.gov/pubmed/23671308 http://dx.doi.org/10.1083/jcb.201304065 |
| Sumario: | Autophagy allows cells to encapsulate parts of their cytosol into unique double-membrane structures. These autophagosomes mature to fuse with lysosomes and deliver the enclosed contents for degradation. Three recent papers, including one by Takáts et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201211160), have taken different routes to discover a role for Syntaxin 17 in the maturation of autophagosomes. |
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