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Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD). The ERAD of reductase slows a rate-limiting step in cholesterol synthesis and results from sterol-i...

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Detalles Bibliográficos
Autores principales:	Faulkner, Rebecca A., Nguyen, Andrew D., Jo, Youngah, DeBose-Boyd, Russell A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653402/ https://www.ncbi.nlm.nih.gov/pubmed/23403031 http://dx.doi.org/10.1194/jlr.M033639

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