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Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells(1)

The mechanism of action of 2-hydroxyoleic acid (2OHOA), a potent antitumor drug, involves the rapid and specific activation of sphingomyelin synthase (SMS), leading to a 4-fold increase in SM mass in tumor cells. In the present study, we investigated the source of the ceramides required to sustain t...

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Detalles Bibliográficos
Autores principales:	Martin, Maria Laura, Liebisch, Gerhard, Lehneis, Stefan, Schmitz, Gerd, Alonso-Sande, María, Bestard-Escalas, Joan, Lopez, Daniel H., García-Verdugo, José Manuel, Soriano-Navarro, Mario, Busquets, Xavier, Escribá, Pablo V., Barceló-Coblijn, Gwendolyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653406/ https://www.ncbi.nlm.nih.gov/pubmed/23471028 http://dx.doi.org/10.1194/jlr.M036749

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