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Roles of lipid metabolism in keloid development

Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth. Although increasing lines of research on keloids have revealed genetic and environmental factors that contribute to the...

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Detalles Bibliográficos
Autores principales: Huang, Chenyu, Ogawa, Rei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653711/
https://www.ncbi.nlm.nih.gov/pubmed/23634948
http://dx.doi.org/10.1186/1476-511X-12-60
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author Huang, Chenyu
Ogawa, Rei
author_facet Huang, Chenyu
Ogawa, Rei
author_sort Huang, Chenyu
collection PubMed
description Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth. Although increasing lines of research on keloids have revealed genetic and environmental factors that contribute to their formation, the etiology of these scars remains unclear. Several studies have suggested the involvement of lipid metabolism, from a nutritional point of view. However, the role that lipid metabolism plays in the pathogenesis and progression of keloids has not previously been reviewed. The progress that has been made in understanding the roles of the pro- and anti-inflammatory lipid mediators in inflammation, and how they relate to the formation and progression of keloids, is also outlined. In particular, the possible relationships between mechanotransduction and lipid metabolites in keloids are explored. Mechanotransduction is the process by which physical forces are converted into biochemical signals that are then integrated into cellular responses. It is possible that lipid rafts and caveolae provide the location of lipid signaling and interactions between these signaling pathways and mechanotransduction. Moreover, interactions between lipid signaling pathway molecules and mechanotransduction molecules have been observed. A better understanding of the lipid profile changes and the functional roles lipid metabolism plays in keloids will help to identify target molecules for the development of novel interventions that can prevent, reduce, or even reverse pathological scar formation and/or progression.
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spelling pubmed-36537112013-05-15 Roles of lipid metabolism in keloid development Huang, Chenyu Ogawa, Rei Lipids Health Dis Review Keloids are common cutaneous pathological scars that are characterised by the histological accumulation of fibroblasts, collagen fibres, and clinically significant invasive growth. Although increasing lines of research on keloids have revealed genetic and environmental factors that contribute to their formation, the etiology of these scars remains unclear. Several studies have suggested the involvement of lipid metabolism, from a nutritional point of view. However, the role that lipid metabolism plays in the pathogenesis and progression of keloids has not previously been reviewed. The progress that has been made in understanding the roles of the pro- and anti-inflammatory lipid mediators in inflammation, and how they relate to the formation and progression of keloids, is also outlined. In particular, the possible relationships between mechanotransduction and lipid metabolites in keloids are explored. Mechanotransduction is the process by which physical forces are converted into biochemical signals that are then integrated into cellular responses. It is possible that lipid rafts and caveolae provide the location of lipid signaling and interactions between these signaling pathways and mechanotransduction. Moreover, interactions between lipid signaling pathway molecules and mechanotransduction molecules have been observed. A better understanding of the lipid profile changes and the functional roles lipid metabolism plays in keloids will help to identify target molecules for the development of novel interventions that can prevent, reduce, or even reverse pathological scar formation and/or progression. BioMed Central 2013-05-01 /pmc/articles/PMC3653711/ /pubmed/23634948 http://dx.doi.org/10.1186/1476-511X-12-60 Text en Copyright © 2013 Huang and Ogawa; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Huang, Chenyu
Ogawa, Rei
Roles of lipid metabolism in keloid development
title Roles of lipid metabolism in keloid development
title_full Roles of lipid metabolism in keloid development
title_fullStr Roles of lipid metabolism in keloid development
title_full_unstemmed Roles of lipid metabolism in keloid development
title_short Roles of lipid metabolism in keloid development
title_sort roles of lipid metabolism in keloid development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653711/
https://www.ncbi.nlm.nih.gov/pubmed/23634948
http://dx.doi.org/10.1186/1476-511X-12-60
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