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A mobile genetic element with unknown function found in distantly related viruses

BACKGROUND: The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS: We have searched GenBank in order to identify all viral accessio...

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Autores principales: Tengs, Torstein, Kristoffersen, Anja Bråthen, Bachvaroff, Tsvetan R, Jonassen, Christine Monceyron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653767/
https://www.ncbi.nlm.nih.gov/pubmed/23618040
http://dx.doi.org/10.1186/1743-422X-10-132
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author Tengs, Torstein
Kristoffersen, Anja Bråthen
Bachvaroff, Tsvetan R
Jonassen, Christine Monceyron
author_facet Tengs, Torstein
Kristoffersen, Anja Bråthen
Bachvaroff, Tsvetan R
Jonassen, Christine Monceyron
author_sort Tengs, Torstein
collection PubMed
description BACKGROUND: The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS: We have searched GenBank in order to identify all viral accessions that have s2m(−like) sequence motifs. Rigorous phylogenetic analyses and constrained tree topology testing were also performed in order to investigate the apparently mobile nature of s2m. RESULTS: The stem-loop s2m structure can be found in four families of + ssRNA viruses; Astroviridae, Caliciviridae, Picornaviridae and Coronaviridae. In all of these virus families, with the possible exception of Caliciviridae, multiple gains and/or losses of s2m would have to be postulated in order to explain the distribution of this character. CONCLUSIONS: s2m appears to be a mobile genetic element with a unique evolutionary history in all of the four virus families where it can be found. Based on our findings and a review of the current literature on s2m, a hypothesis implying an RNAi-like function for the s2m element is also outlined.
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spelling pubmed-36537672013-05-15 A mobile genetic element with unknown function found in distantly related viruses Tengs, Torstein Kristoffersen, Anja Bråthen Bachvaroff, Tsvetan R Jonassen, Christine Monceyron Virol J Research BACKGROUND: The genetic element s2m seems to represent one of very few examples of mobile genetic elements in viruses. The function remains obscure and a scattered taxonomical distribution has been reported by numerous groups. METHODS: We have searched GenBank in order to identify all viral accessions that have s2m(−like) sequence motifs. Rigorous phylogenetic analyses and constrained tree topology testing were also performed in order to investigate the apparently mobile nature of s2m. RESULTS: The stem-loop s2m structure can be found in four families of + ssRNA viruses; Astroviridae, Caliciviridae, Picornaviridae and Coronaviridae. In all of these virus families, with the possible exception of Caliciviridae, multiple gains and/or losses of s2m would have to be postulated in order to explain the distribution of this character. CONCLUSIONS: s2m appears to be a mobile genetic element with a unique evolutionary history in all of the four virus families where it can be found. Based on our findings and a review of the current literature on s2m, a hypothesis implying an RNAi-like function for the s2m element is also outlined. BioMed Central 2013-04-25 /pmc/articles/PMC3653767/ /pubmed/23618040 http://dx.doi.org/10.1186/1743-422X-10-132 Text en Copyright © 2013 Tengs et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tengs, Torstein
Kristoffersen, Anja Bråthen
Bachvaroff, Tsvetan R
Jonassen, Christine Monceyron
A mobile genetic element with unknown function found in distantly related viruses
title A mobile genetic element with unknown function found in distantly related viruses
title_full A mobile genetic element with unknown function found in distantly related viruses
title_fullStr A mobile genetic element with unknown function found in distantly related viruses
title_full_unstemmed A mobile genetic element with unknown function found in distantly related viruses
title_short A mobile genetic element with unknown function found in distantly related viruses
title_sort mobile genetic element with unknown function found in distantly related viruses
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653767/
https://www.ncbi.nlm.nih.gov/pubmed/23618040
http://dx.doi.org/10.1186/1743-422X-10-132
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