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Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo

Peripheral leukocytes can exacerbate brain damage by release of cytotoxic mediators that disrupt blood-brain barrier (BBB) function. One of the oxidants released by activated leukocytes is hypochlorous acid (HOCl) formed via the myeloperoxidase (MPO)-H(2)O(2)-Cl(−) system. In the present study we ex...

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Detalles Bibliográficos
Autores principales:	Üllen, Andreas, Singewald, Evelin, Konya, Viktoria, Fauler, Günter, Reicher, Helga, Nusshold, Christoph, Hammer, Astrid, Kratky, Dagmar, Heinemann, Akos, Holzer, Peter, Malle, Ernst, Sattler, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653856/ https://www.ncbi.nlm.nih.gov/pubmed/23691142 http://dx.doi.org/10.1371/journal.pone.0064034

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