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Epiblast Ground State Is Controlled by Canonical Wnt/β-Catenin Signaling in the Postimplantation Mouse Embryo and Epiblast Stem Cells

Epiblast stem cells (EpiSCs) are primed pluripotent stem cells and can be derived from postimplantation mouse embryos. We now show that the absence of canonical Wnt/β-catenin signaling is essential for maintenance of the undifferentiated state in mouse EpiSCs and in the epiblast of mouse embryos. At...

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Detalles Bibliográficos
Autores principales: Sumi, Tomoyuki, Oki, Shinya, Kitajima, Keiko, Meno, Chikara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653965/
https://www.ncbi.nlm.nih.gov/pubmed/23691040
http://dx.doi.org/10.1371/journal.pone.0063378

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