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Procalcitonin as a biomarker of infectious diseases
Traditional biomarkers, including C-reactive protein, leukocytes, erythrocyte sedimentation rate, and clinical signs and symptoms, are not sufficiently sensitive or specific enough to guide treatment decisions in infectious febrile diseases. Procalcitonin (PCT) is synthesized by a large number of ti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association of Internal Medicine
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654123/ https://www.ncbi.nlm.nih.gov/pubmed/23682219 http://dx.doi.org/10.3904/kjim.2013.28.3.285 |
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author | Lee, Hyuck |
author_facet | Lee, Hyuck |
author_sort | Lee, Hyuck |
collection | PubMed |
description | Traditional biomarkers, including C-reactive protein, leukocytes, erythrocyte sedimentation rate, and clinical signs and symptoms, are not sufficiently sensitive or specific enough to guide treatment decisions in infectious febrile diseases. Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. A growing body of evidence supports the use of PCT as a marker to improve the diagnosis of bacterial infections and to guide antibiotic therapy. Clinically, PCT levels may help guide the need for empirical antibiotic therapy, source control for infections, and duration of antibiotic therapy. The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and to discuss the reliability of this marker in order to provide physicians with an overview of the potential for PCT to guide antibiotic therapy. |
format | Online Article Text |
id | pubmed-3654123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-36541232013-05-16 Procalcitonin as a biomarker of infectious diseases Lee, Hyuck Korean J Intern Med Review Traditional biomarkers, including C-reactive protein, leukocytes, erythrocyte sedimentation rate, and clinical signs and symptoms, are not sufficiently sensitive or specific enough to guide treatment decisions in infectious febrile diseases. Procalcitonin (PCT) is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi, and some parasites. A growing body of evidence supports the use of PCT as a marker to improve the diagnosis of bacterial infections and to guide antibiotic therapy. Clinically, PCT levels may help guide the need for empirical antibiotic therapy, source control for infections, and duration of antibiotic therapy. The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and to discuss the reliability of this marker in order to provide physicians with an overview of the potential for PCT to guide antibiotic therapy. The Korean Association of Internal Medicine 2013-05 2013-05-01 /pmc/articles/PMC3654123/ /pubmed/23682219 http://dx.doi.org/10.3904/kjim.2013.28.3.285 Text en Copyright © 2013 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lee, Hyuck Procalcitonin as a biomarker of infectious diseases |
title | Procalcitonin as a biomarker of infectious diseases |
title_full | Procalcitonin as a biomarker of infectious diseases |
title_fullStr | Procalcitonin as a biomarker of infectious diseases |
title_full_unstemmed | Procalcitonin as a biomarker of infectious diseases |
title_short | Procalcitonin as a biomarker of infectious diseases |
title_sort | procalcitonin as a biomarker of infectious diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654123/ https://www.ncbi.nlm.nih.gov/pubmed/23682219 http://dx.doi.org/10.3904/kjim.2013.28.3.285 |
work_keys_str_mv | AT leehyuck procalcitoninasabiomarkerofinfectiousdiseases |