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2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2)

Two-pore domain K(+) (KCNK, K(2)P) channels underlie the “leak” (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability. These channels have been reported to be modulated by several physical and chemical stimuli. The compound 2-a...

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Detalles Bibliográficos
Autores principales:	Beltrán, Leopoldo, Beltrán, Madeline, Aguado, Ainhara, Gisselmann, Günter, Hatt, Hanns
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654204/ https://www.ncbi.nlm.nih.gov/pubmed/23720627 http://dx.doi.org/10.3389/fphar.2013.00063

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