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Effect of Polyherbal Mixtures on the Treatment of Diabetes

The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures....

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Autores principales: Panda, Aparajeya, Jena, Somanatha, Sahu, Pramod Kumar, Nayak, Sanghamitra, Padhi, Payodhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654233/
https://www.ncbi.nlm.nih.gov/pubmed/23691349
http://dx.doi.org/10.1155/2013/934797
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author Panda, Aparajeya
Jena, Somanatha
Sahu, Pramod Kumar
Nayak, Sanghamitra
Padhi, Payodhar
author_facet Panda, Aparajeya
Jena, Somanatha
Sahu, Pramod Kumar
Nayak, Sanghamitra
Padhi, Payodhar
author_sort Panda, Aparajeya
collection PubMed
description The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21 days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures.
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spelling pubmed-36542332013-05-20 Effect of Polyherbal Mixtures on the Treatment of Diabetes Panda, Aparajeya Jena, Somanatha Sahu, Pramod Kumar Nayak, Sanghamitra Padhi, Payodhar ISRN Endocrinol Research Article The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w. produced a significant decrease in blood glucose level by 69.6%, 70.97%, 64.45%, 71.82%, and 64.44% after 21 days of treatment. The elevated level of SGPT, SGOT, and ALP in the diabetic controlled group reflected the significant alteration of liver function by STZ induction and was found to be equipotent to glibenclamide in restoration of the elevated enzyme levels to normal. The elevated lipid levels (triglyceride and total cholesterol) were restored to near normal by these mixtures for all the estimated parameters. The results of the mixtures on treated group were found to restore the glycemic level to the near normal level thereby indicating antihyperglycemic activity of the formulated mixtures. Hindawi Publishing Corporation 2013-04-16 /pmc/articles/PMC3654233/ /pubmed/23691349 http://dx.doi.org/10.1155/2013/934797 Text en Copyright © 2013 Aparajeya Panda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Panda, Aparajeya
Jena, Somanatha
Sahu, Pramod Kumar
Nayak, Sanghamitra
Padhi, Payodhar
Effect of Polyherbal Mixtures on the Treatment of Diabetes
title Effect of Polyherbal Mixtures on the Treatment of Diabetes
title_full Effect of Polyherbal Mixtures on the Treatment of Diabetes
title_fullStr Effect of Polyherbal Mixtures on the Treatment of Diabetes
title_full_unstemmed Effect of Polyherbal Mixtures on the Treatment of Diabetes
title_short Effect of Polyherbal Mixtures on the Treatment of Diabetes
title_sort effect of polyherbal mixtures on the treatment of diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654233/
https://www.ncbi.nlm.nih.gov/pubmed/23691349
http://dx.doi.org/10.1155/2013/934797
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