Mechanisms Mediating Spinal and Bulbar Muscular Atrophy: Investigations into Polyglutamine-Expanded Androgen Receptor Function and Dysfunction

Spinal and bulbar muscular atrophy (SBMA, Kennedy’s disease), a late-onset neuromuscular disorder, is caused by expansion of the polymorphic polyglutamine tract in the androgen receptor (AR). The AR is a ligand-activated transcription factor, but plays roles in other cellular pathways. In SBMA, sele...

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Detalles Bibliográficos
Autores principales: Beitel, Lenore K., Alvarado, Carlos, Mokhtar, Shaza, Paliouras, Miltiadis, Trifiro, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654311/
https://www.ncbi.nlm.nih.gov/pubmed/23720649
http://dx.doi.org/10.3389/fneur.2013.00053

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