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Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review
Posttraumatic stress disorder (PTSD) develops in approximately one-quarter of trauma-exposed individuals, leading us and others to question the mechanisms underlying this heterogeneous response to trauma. We suggest that the reasons for the heterogeneity relate to a complex interaction between genes...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654332/ https://www.ncbi.nlm.nih.gov/pubmed/23710355 http://dx.doi.org/10.1155/2013/417010 |
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author | Heinzelmann, Morgan Gill, Jessica |
author_facet | Heinzelmann, Morgan Gill, Jessica |
author_sort | Heinzelmann, Morgan |
collection | PubMed |
description | Posttraumatic stress disorder (PTSD) develops in approximately one-quarter of trauma-exposed individuals, leading us and others to question the mechanisms underlying this heterogeneous response to trauma. We suggest that the reasons for the heterogeneity relate to a complex interaction between genes and the environment, shaping each individual's recovery trajectory based on both historical and trauma-specific variables. Epigenetic modifications provide a unique opportunity to elucidate how preexisting risk factors may contribute to PTSD risk through changes in the methylation of DNA. Preexisting risks for PTSD, including depression, stress, and trauma, result in differential DNA methylation of endocrine genes, which may then result in a different biological responses to trauma and subsequently a greater risk for PTSD onset. Although these relationships are complex and currently inadequately described, we provide a critical review of recent studies to examine how differences in genetic and proteomic biomarkers shape an individual's vulnerability to PTSD development, thereby contributing to a heterogeneous response to trauma. |
format | Online Article Text |
id | pubmed-3654332 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36543322013-05-24 Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review Heinzelmann, Morgan Gill, Jessica Nurs Res Pract Review Article Posttraumatic stress disorder (PTSD) develops in approximately one-quarter of trauma-exposed individuals, leading us and others to question the mechanisms underlying this heterogeneous response to trauma. We suggest that the reasons for the heterogeneity relate to a complex interaction between genes and the environment, shaping each individual's recovery trajectory based on both historical and trauma-specific variables. Epigenetic modifications provide a unique opportunity to elucidate how preexisting risk factors may contribute to PTSD risk through changes in the methylation of DNA. Preexisting risks for PTSD, including depression, stress, and trauma, result in differential DNA methylation of endocrine genes, which may then result in a different biological responses to trauma and subsequently a greater risk for PTSD onset. Although these relationships are complex and currently inadequately described, we provide a critical review of recent studies to examine how differences in genetic and proteomic biomarkers shape an individual's vulnerability to PTSD development, thereby contributing to a heterogeneous response to trauma. Hindawi Publishing Corporation 2013 2013-04-17 /pmc/articles/PMC3654332/ /pubmed/23710355 http://dx.doi.org/10.1155/2013/417010 Text en Copyright © 2013 M. Heinzelmann and J. Gill. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Heinzelmann, Morgan Gill, Jessica Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review |
title | Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review |
title_full | Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review |
title_fullStr | Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review |
title_full_unstemmed | Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review |
title_short | Epigenetic Mechanisms Shape the Biological Response to Trauma and Risk for PTSD: A Critical Review |
title_sort | epigenetic mechanisms shape the biological response to trauma and risk for ptsd: a critical review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654332/ https://www.ncbi.nlm.nih.gov/pubmed/23710355 http://dx.doi.org/10.1155/2013/417010 |
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