Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions

The receptor tyrosine kinase ErbB2 is a breast cancer biomarker whose posttranslational modifications (PTMs) are a key indicator of its activation. Quantifying the expression and PTMs of biomarkers such as ErbB2 by selected reaction monitoring (SRM) mass spectrometry has several limitations, includi...

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Detalles Bibliográficos
Autores principales: Held, Jason M., Schilling, Birgit, D'Souza, Alexandria K., Srinivasan, Tara, Behring, Jessica B., Sorensen, Dylan J., Benz, Christopher C., Gibson, Bradford W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654371/
https://www.ncbi.nlm.nih.gov/pubmed/23710360
http://dx.doi.org/10.1155/2013/791985

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