Cargando…

Two unlike cousins: Candida albicans and C. glabrata infection strategies

Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutr...

Descripción completa

Detalles Bibliográficos
Autores principales: Brunke, Sascha, Hube, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654559/
https://www.ncbi.nlm.nih.gov/pubmed/23253282
http://dx.doi.org/10.1111/cmi.12091
_version_ 1782269578491985920
author Brunke, Sascha
Hube, Bernhard
author_facet Brunke, Sascha
Hube, Bernhard
author_sort Brunke, Sascha
collection PubMed
description Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C. albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C. glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general.
format Online
Article
Text
id pubmed-3654559
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-36545592013-05-17 Two unlike cousins: Candida albicans and C. glabrata infection strategies Brunke, Sascha Hube, Bernhard Cell Microbiol Microreviews Candida albicans and C. glabrata are the two most common pathogenic yeasts of humans, yet they are phylogenetically, genetically and phenotypically very different. In this review, we compare and contrast the strategies of C. albicans and C. glabrata to attach to and invade into the host, obtain nutrients and evade the host immune response. Although their strategies share some basic concepts, they differ greatly in their outcome. While C. albicans follows an aggressive strategy to subvert the host response and to obtain nutrients for its survival, C. glabrata seems to have evolved a strategy which is based on stealth, evasion and persistence, without causing severe damage in murine models. However, both fungi are successful as commensals and as pathogens of humans. Understanding these strategies will help in finding novel ways to fight Candida, and fungal infections in general. Blackwell Publishing Ltd 2013-05 2013-01-14 /pmc/articles/PMC3654559/ /pubmed/23253282 http://dx.doi.org/10.1111/cmi.12091 Text en Copyright © 2013 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Microreviews
Brunke, Sascha
Hube, Bernhard
Two unlike cousins: Candida albicans and C. glabrata infection strategies
title Two unlike cousins: Candida albicans and C. glabrata infection strategies
title_full Two unlike cousins: Candida albicans and C. glabrata infection strategies
title_fullStr Two unlike cousins: Candida albicans and C. glabrata infection strategies
title_full_unstemmed Two unlike cousins: Candida albicans and C. glabrata infection strategies
title_short Two unlike cousins: Candida albicans and C. glabrata infection strategies
title_sort two unlike cousins: candida albicans and c. glabrata infection strategies
topic Microreviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654559/
https://www.ncbi.nlm.nih.gov/pubmed/23253282
http://dx.doi.org/10.1111/cmi.12091
work_keys_str_mv AT brunkesascha twounlikecousinscandidaalbicansandcglabratainfectionstrategies
AT hubebernhard twounlikecousinscandidaalbicansandcglabratainfectionstrategies