High-density lipoproteins delivering interleukin-15

Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this...

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Detalles Bibliográficos
Autores principales: Ochoa, Maria C., Melero, Ignacio, Berraondo, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654572/
https://www.ncbi.nlm.nih.gov/pubmed/23734302
http://dx.doi.org/10.4161/onci.23410
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author Ochoa, Maria C.
Melero, Ignacio
Berraondo, Pedro
author_facet Ochoa, Maria C.
Melero, Ignacio
Berraondo, Pedro
author_sort Ochoa, Maria C.
collection PubMed
description Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation.
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spelling pubmed-36545722013-06-03 High-density lipoproteins delivering interleukin-15 Ochoa, Maria C. Melero, Ignacio Berraondo, Pedro Oncoimmunology Author's View Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654572/ /pubmed/23734302 http://dx.doi.org/10.4161/onci.23410 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Ochoa, Maria C.
Melero, Ignacio
Berraondo, Pedro
High-density lipoproteins delivering interleukin-15
title High-density lipoproteins delivering interleukin-15
title_full High-density lipoproteins delivering interleukin-15
title_fullStr High-density lipoproteins delivering interleukin-15
title_full_unstemmed High-density lipoproteins delivering interleukin-15
title_short High-density lipoproteins delivering interleukin-15
title_sort high-density lipoproteins delivering interleukin-15
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654572/
https://www.ncbi.nlm.nih.gov/pubmed/23734302
http://dx.doi.org/10.4161/onci.23410
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