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Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes

Although γδ T cells are known to exert both tumor-preventing and tumor-promoting activity, there is still little information on the functional characteristics and clinical significance of γδ T cells isolated from the tumor site. In a recent study, we have investigated the distribution of different γ...

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Detalles Bibliográficos
Autores principales: Dieli, Francesco, Stassi, Giorgio, Todaro, Matilde, Meraviglia, Serena, Caccamo, Nadia, Cordova, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654575/
https://www.ncbi.nlm.nih.gov/pubmed/23734305
http://dx.doi.org/10.4161/onci.23434
Descripción
Sumario:Although γδ T cells are known to exert both tumor-preventing and tumor-promoting activity, there is still little information on the functional characteristics and clinical significance of γδ T cells isolated from the tumor site. In a recent study, we have investigated the distribution of different γδ T-cell populations in melanoma and their impact on disease outcome.