Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines

Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for the anticancer immunotherapy. Given the weak antigenic nature of most TAAs, however, the efficacy of TAA-based vaccines requires adjuvants exerting potent immunostimulatory functions. Co-stimulatory members of the t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shirwan, Haval, Sharma, Rajesh K., Srivastava, Abhishek K., Yolcu, Esma S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654576/
https://www.ncbi.nlm.nih.gov/pubmed/23734306
http://dx.doi.org/10.4161/onci.23440
_version_ 1782269583222112256
author Shirwan, Haval
Sharma, Rajesh K.
Srivastava, Abhishek K.
Yolcu, Esma S.
author_facet Shirwan, Haval
Sharma, Rajesh K.
Srivastava, Abhishek K.
Yolcu, Esma S.
author_sort Shirwan, Haval
collection PubMed
description Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for the anticancer immunotherapy. Given the weak antigenic nature of most TAAs, however, the efficacy of TAA-based vaccines requires adjuvants exerting potent immunostimulatory functions. Co-stimulatory members of the tumor necrosis factor ligand (TNFL) family may be used in this sense due to their pleiotropic and robust effects on cells of innate, adaptive and regulatory immune responses.
format Online
Article
Text
id pubmed-3654576
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36545762013-06-03 Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines Shirwan, Haval Sharma, Rajesh K. Srivastava, Abhishek K. Yolcu, Esma S. Oncoimmunology Author's View Tumor-associated antigen (TAA) subunit-based vaccines constitute promising tools for the anticancer immunotherapy. Given the weak antigenic nature of most TAAs, however, the efficacy of TAA-based vaccines requires adjuvants exerting potent immunostimulatory functions. Co-stimulatory members of the tumor necrosis factor ligand (TNFL) family may be used in this sense due to their pleiotropic and robust effects on cells of innate, adaptive and regulatory immune responses. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654576/ /pubmed/23734306 http://dx.doi.org/10.4161/onci.23440 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Shirwan, Haval
Sharma, Rajesh K.
Srivastava, Abhishek K.
Yolcu, Esma S.
Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
title Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
title_full Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
title_fullStr Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
title_full_unstemmed Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
title_short Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
title_sort co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654576/
https://www.ncbi.nlm.nih.gov/pubmed/23734306
http://dx.doi.org/10.4161/onci.23440
work_keys_str_mv AT shirwanhaval costimulatorytumornecrosisfactorligandsasadjuvantsforthedevelopmentofsubunitbasedanticancervaccines
AT sharmarajeshk costimulatorytumornecrosisfactorligandsasadjuvantsforthedevelopmentofsubunitbasedanticancervaccines
AT srivastavaabhishekk costimulatorytumornecrosisfactorligandsasadjuvantsforthedevelopmentofsubunitbasedanticancervaccines
AT yolcuesmas costimulatorytumornecrosisfactorligandsasadjuvantsforthedevelopmentofsubunitbasedanticancervaccines

Ejemplares similares