Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance

CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin’s lymphoma.

Detalles Bibliográficos
Autores principales: Pang, Wan Lu, Ho, Weng Tong, Schwarz, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654577/
https://www.ncbi.nlm.nih.gov/pubmed/23734307
http://dx.doi.org/10.4161/onci.23441
_version_ 1782269583517810688
author Pang, Wan Lu
Ho, Weng Tong
Schwarz, Herbert
author_facet Pang, Wan Lu
Ho, Weng Tong
Schwarz, Herbert
author_sort Pang, Wan Lu
collection PubMed
description CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin’s lymphoma.
format Online
Article
Text
id pubmed-3654577
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36545772013-06-03 Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance Pang, Wan Lu Ho, Weng Tong Schwarz, Herbert Oncoimmunology Author's View CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin’s lymphoma. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654577/ /pubmed/23734307 http://dx.doi.org/10.4161/onci.23441 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Pang, Wan Lu
Ho, Weng Tong
Schwarz, Herbert
Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
title Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
title_full Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
title_fullStr Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
title_full_unstemmed Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
title_short Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
title_sort ectopic cd137 expression facilitates the escape of hodgkin and reed-sternberg cells from immunosurveillance
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654577/
https://www.ncbi.nlm.nih.gov/pubmed/23734307
http://dx.doi.org/10.4161/onci.23441
work_keys_str_mv AT pangwanlu ectopiccd137expressionfacilitatestheescapeofhodgkinandreedsternbergcellsfromimmunosurveillance
AT howengtong ectopiccd137expressionfacilitatestheescapeofhodgkinandreedsternbergcellsfromimmunosurveillance
AT schwarzherbert ectopiccd137expressionfacilitatestheescapeofhodgkinandreedsternbergcellsfromimmunosurveillance

Ejemplares similares