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Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance

CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin’s lymphoma.

Detalles Bibliográficos
Autores principales:	Pang, Wan Lu, Ho, Weng Tong, Schwarz, Herbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Author's View
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654577/ https://www.ncbi.nlm.nih.gov/pubmed/23734307 http://dx.doi.org/10.4161/onci.23441

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