Targeting cathepsin G in myeloid leukemia

Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and—aberrantly—by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute pr...

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Detalles Bibliográficos
Autor principal: Alatrash, Gheath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654578/
https://www.ncbi.nlm.nih.gov/pubmed/23734308
http://dx.doi.org/10.4161/onci.23442
Descripción
Sumario:Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and—aberrantly—by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute promising targets for the immunotherapy of myeloid leukemia.

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