Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands

In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that TLR3 ligands can operate through three independent mechanisms: by directly killing TLR3-expressing cancer cells, by inducing T- and natural...

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Detalles Bibliográficos
Autores principales: Chew, Valerie, Abastado, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654580/
https://www.ncbi.nlm.nih.gov/pubmed/23734310
http://dx.doi.org/10.4161/onci.23493
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author Chew, Valerie
Abastado, Jean-Pierre
author_facet Chew, Valerie
Abastado, Jean-Pierre
author_sort Chew, Valerie
collection PubMed
description In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that TLR3 ligands can operate through three independent mechanisms: by directly killing TLR3-expressing cancer cells, by inducing T- and natural killer (NK)-cell infiltration and by activating TLR3-expressing NK cells.
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spelling pubmed-36545802013-06-03 Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands Chew, Valerie Abastado, Jean-Pierre Oncoimmunology Author's View In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that TLR3 ligands can operate through three independent mechanisms: by directly killing TLR3-expressing cancer cells, by inducing T- and natural killer (NK)-cell infiltration and by activating TLR3-expressing NK cells. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654580/ /pubmed/23734310 http://dx.doi.org/10.4161/onci.23493 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Chew, Valerie
Abastado, Jean-Pierre
Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
title Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
title_full Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
title_fullStr Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
title_full_unstemmed Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
title_short Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
title_sort immunomodulation of the tumor microenvironment by toll-like receptor-3 (tlr3) ligands
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654580/
https://www.ncbi.nlm.nih.gov/pubmed/23734310
http://dx.doi.org/10.4161/onci.23493
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