NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?

Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue...

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Detalles Bibliográficos
Autores principales: Vacca, Paola, Martini, Stefania, Mingari, Maria C., Moretta, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654587/
https://www.ncbi.nlm.nih.gov/pubmed/23734317
http://dx.doi.org/10.4161/onci.23638
Descripción
Sumario:Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue for the development of novel approaches for tumor immunotherapy.

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