NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?

Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue...

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Autores principales: Vacca, Paola, Martini, Stefania, Mingari, Maria C., Moretta, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654587/
https://www.ncbi.nlm.nih.gov/pubmed/23734317
http://dx.doi.org/10.4161/onci.23638
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author Vacca, Paola
Martini, Stefania
Mingari, Maria C.
Moretta, Lorenzo
author_facet Vacca, Paola
Martini, Stefania
Mingari, Maria C.
Moretta, Lorenzo
author_sort Vacca, Paola
collection PubMed
description Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue for the development of novel approaches for tumor immunotherapy.
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spelling pubmed-36545872013-06-03 NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy? Vacca, Paola Martini, Stefania Mingari, Maria C. Moretta, Lorenzo Oncoimmunology Author's View Natural killer (NK) cells exert potent antitumor activity. However, NK cells infiltrating solid tumors are severely impaired in their function. Remarkably, NK cells isolated from malignant pleural effusions kill very efficiently tumor cells upon exposure to interleukin-2, offering an important clue for the development of novel approaches for tumor immunotherapy. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654587/ /pubmed/23734317 http://dx.doi.org/10.4161/onci.23638 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Vacca, Paola
Martini, Stefania
Mingari, Maria C.
Moretta, Lorenzo
NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
title NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
title_full NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
title_fullStr NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
title_full_unstemmed NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
title_short NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
title_sort nk cells from malignant pleural effusions are potent antitumor effectors: a clue for adoptive immunotherapy?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654587/
https://www.ncbi.nlm.nih.gov/pubmed/23734317
http://dx.doi.org/10.4161/onci.23638
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