A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system

Bispecific T-cell engagers (BiTEs) may break multiple barriers that currently limit the use of immunotherapy in glioblastoma patients. We have recently described a novel BiTE specific for a mutated form of the epidermal growth factor receptor, EGFRvIII, that exerts potent antineoplastic effects agai...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Bryan D., Pastan, Ira, Bigner, Darell D., Sampson, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654588/
https://www.ncbi.nlm.nih.gov/pubmed/23734318
http://dx.doi.org/10.4161/onci.23639
_version_ 1782269586088919040
author Choi, Bryan D.
Pastan, Ira
Bigner, Darell D.
Sampson, John H.
author_facet Choi, Bryan D.
Pastan, Ira
Bigner, Darell D.
Sampson, John H.
author_sort Choi, Bryan D.
collection PubMed
description Bispecific T-cell engagers (BiTEs) may break multiple barriers that currently limit the use of immunotherapy in glioblastoma patients. We have recently described a novel BiTE specific for a mutated form of the epidermal growth factor receptor, EGFRvIII, that exerts potent antineoplastic effects against established invasive tumors of the brain.
format Online
Article
Text
id pubmed-3654588
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36545882013-06-03 A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system Choi, Bryan D. Pastan, Ira Bigner, Darell D. Sampson, John H. Oncoimmunology Author's View Bispecific T-cell engagers (BiTEs) may break multiple barriers that currently limit the use of immunotherapy in glioblastoma patients. We have recently described a novel BiTE specific for a mutated form of the epidermal growth factor receptor, EGFRvIII, that exerts potent antineoplastic effects against established invasive tumors of the brain. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654588/ /pubmed/23734318 http://dx.doi.org/10.4161/onci.23639 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Choi, Bryan D.
Pastan, Ira
Bigner, Darell D.
Sampson, John H.
A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
title A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
title_full A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
title_fullStr A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
title_full_unstemmed A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
title_short A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
title_sort novel bispecific antibody recruits t cells to eradicate tumors in the “immunologically privileged” central nervous system
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654588/
https://www.ncbi.nlm.nih.gov/pubmed/23734318
http://dx.doi.org/10.4161/onci.23639
work_keys_str_mv AT choibryand anovelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT pastanira anovelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT bignerdarelld anovelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT sampsonjohnh anovelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT choibryand novelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT pastanira novelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT bignerdarelld novelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem
AT sampsonjohnh novelbispecificantibodyrecruitstcellstoeradicatetumorsintheimmunologicallyprivilegedcentralnervoussystem

Ejemplares similares