Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy

Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit...

Descripción completa

Detalles Bibliográficos
Autores principales: Alvarez-Breckenridge, Christopher A., Yu, Jianhua, Caligiuri, Michael A., Chiocca, E. Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654589/
https://www.ncbi.nlm.nih.gov/pubmed/23734319
http://dx.doi.org/10.4161/onci.23658
_version_ 1782269586320654336
author Alvarez-Breckenridge, Christopher A.
Yu, Jianhua
Caligiuri, Michael A.
Chiocca, E. Antonio
author_facet Alvarez-Breckenridge, Christopher A.
Yu, Jianhua
Caligiuri, Michael A.
Chiocca, E. Antonio
author_sort Alvarez-Breckenridge, Christopher A.
collection PubMed
description Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors.
format Online
Article
Text
id pubmed-3654589
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-36545892013-06-03 Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy Alvarez-Breckenridge, Christopher A. Yu, Jianhua Caligiuri, Michael A. Chiocca, E. Antonio Oncoimmunology Author's View Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654589/ /pubmed/23734319 http://dx.doi.org/10.4161/onci.23658 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Alvarez-Breckenridge, Christopher A.
Yu, Jianhua
Caligiuri, Michael A.
Chiocca, E. Antonio
Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
title Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
title_full Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
title_fullStr Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
title_full_unstemmed Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
title_short Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
title_sort uncovering a novel mechanism whereby nk cells interfere with glioblastoma virotherapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654589/
https://www.ncbi.nlm.nih.gov/pubmed/23734319
http://dx.doi.org/10.4161/onci.23658
work_keys_str_mv AT alvarezbreckenridgechristophera uncoveringanovelmechanismwherebynkcellsinterferewithglioblastomavirotherapy
AT yujianhua uncoveringanovelmechanismwherebynkcellsinterferewithglioblastomavirotherapy
AT caligiurimichaela uncoveringanovelmechanismwherebynkcellsinterferewithglioblastomavirotherapy
AT chioccaeantonio uncoveringanovelmechanismwherebynkcellsinterferewithglioblastomavirotherapy

Ejemplares similares