The CCL5/CCR5 axis promotes metastasis in basal breast cancer

Recently, we have shown that the CCL5/CCR5 axis is active in patients affected by an aggressive basal subtype of breast cancer. Using preclinical models, we have demonstrated that CCR5 promotes breast cancer invasiveness and metastatic potential, while CCR5 inhibition abrogates them. Thus, CCR5 anta...

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Detalles Bibliográficos
Autores principales: Velasco-Velázquez, Marco, Pestell, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654591/
https://www.ncbi.nlm.nih.gov/pubmed/23734321
http://dx.doi.org/10.4161/onci.23660
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author Velasco-Velázquez, Marco
Pestell, Richard G.
author_facet Velasco-Velázquez, Marco
Pestell, Richard G.
author_sort Velasco-Velázquez, Marco
collection PubMed
description Recently, we have shown that the CCL5/CCR5 axis is active in patients affected by an aggressive basal subtype of breast cancer. Using preclinical models, we have demonstrated that CCR5 promotes breast cancer invasiveness and metastatic potential, while CCR5 inhibition abrogates them. Thus, CCR5 antagonists may constitute an alternative therapeutic approach for patients affected by metastatic basal breast cancer.
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spelling pubmed-36545912013-06-03 The CCL5/CCR5 axis promotes metastasis in basal breast cancer Velasco-Velázquez, Marco Pestell, Richard G. Oncoimmunology Author's View Recently, we have shown that the CCL5/CCR5 axis is active in patients affected by an aggressive basal subtype of breast cancer. Using preclinical models, we have demonstrated that CCR5 promotes breast cancer invasiveness and metastatic potential, while CCR5 inhibition abrogates them. Thus, CCR5 antagonists may constitute an alternative therapeutic approach for patients affected by metastatic basal breast cancer. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654591/ /pubmed/23734321 http://dx.doi.org/10.4161/onci.23660 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Velasco-Velázquez, Marco
Pestell, Richard G.
The CCL5/CCR5 axis promotes metastasis in basal breast cancer
title The CCL5/CCR5 axis promotes metastasis in basal breast cancer
title_full The CCL5/CCR5 axis promotes metastasis in basal breast cancer
title_fullStr The CCL5/CCR5 axis promotes metastasis in basal breast cancer
title_full_unstemmed The CCL5/CCR5 axis promotes metastasis in basal breast cancer
title_short The CCL5/CCR5 axis promotes metastasis in basal breast cancer
title_sort ccl5/ccr5 axis promotes metastasis in basal breast cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654591/
https://www.ncbi.nlm.nih.gov/pubmed/23734321
http://dx.doi.org/10.4161/onci.23660
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