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Myeloid derived suppressor cells: Targets for therapy

The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-d...

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Detalles Bibliográficos
Autores principales: Waldron, Todd J., Quatromoni, Jon G., Karakasheva, Tatiana A., Singhal, Sunil, Rustgi, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654606/
https://www.ncbi.nlm.nih.gov/pubmed/23734336
http://dx.doi.org/10.4161/onci.24117
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author Waldron, Todd J.
Quatromoni, Jon G.
Karakasheva, Tatiana A.
Singhal, Sunil
Rustgi, Anil K.
author_facet Waldron, Todd J.
Quatromoni, Jon G.
Karakasheva, Tatiana A.
Singhal, Sunil
Rustgi, Anil K.
author_sort Waldron, Todd J.
collection PubMed
description The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-derived signals, MDSCs inhibit the ability of the host to mount an anti-tumor immune response via their capacity to suppress both the innate and adaptive immune systems. Despite their relatively recent discovery and characterization, anti-MDSC agents have been identified, which may improve immunotherapy efficacy.
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spelling pubmed-36546062013-06-03 Myeloid derived suppressor cells: Targets for therapy Waldron, Todd J. Quatromoni, Jon G. Karakasheva, Tatiana A. Singhal, Sunil Rustgi, Anil K. Oncoimmunology Review The goal of achieving measurable response with cancer immunotherapy requires counteracting the immunosuppressive characteristics of tumors. One of the mechanisms that tumors utilize to escape immunosurveillance is the activation of myeloid derived suppressor cells (MDSCs). Upon activation by tumor-derived signals, MDSCs inhibit the ability of the host to mount an anti-tumor immune response via their capacity to suppress both the innate and adaptive immune systems. Despite their relatively recent discovery and characterization, anti-MDSC agents have been identified, which may improve immunotherapy efficacy. Landes Bioscience 2013-04-01 2013-04-01 /pmc/articles/PMC3654606/ /pubmed/23734336 http://dx.doi.org/10.4161/onci.24117 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Waldron, Todd J.
Quatromoni, Jon G.
Karakasheva, Tatiana A.
Singhal, Sunil
Rustgi, Anil K.
Myeloid derived suppressor cells: Targets for therapy
title Myeloid derived suppressor cells: Targets for therapy
title_full Myeloid derived suppressor cells: Targets for therapy
title_fullStr Myeloid derived suppressor cells: Targets for therapy
title_full_unstemmed Myeloid derived suppressor cells: Targets for therapy
title_short Myeloid derived suppressor cells: Targets for therapy
title_sort myeloid derived suppressor cells: targets for therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654606/
https://www.ncbi.nlm.nih.gov/pubmed/23734336
http://dx.doi.org/10.4161/onci.24117
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