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Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature

Hypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies. We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma. Complete remission was achieved with chemotherapy; however, hyp...

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Autores principales: Moita, Filipa, Bogalho, Isabel, Alaiz, Helena, Parreira, Joana, Frade, Maria Jesus, Nunes, Albertina, Gomes da Silva, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654631/
https://www.ncbi.nlm.nih.gov/pubmed/23710385
http://dx.doi.org/10.1155/2013/652745
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author Moita, Filipa
Bogalho, Isabel
Alaiz, Helena
Parreira, Joana
Frade, Maria Jesus
Nunes, Albertina
Gomes da Silva, Maria
author_facet Moita, Filipa
Bogalho, Isabel
Alaiz, Helena
Parreira, Joana
Frade, Maria Jesus
Nunes, Albertina
Gomes da Silva, Maria
author_sort Moita, Filipa
collection PubMed
description Hypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies. We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma. Complete remission was achieved with chemotherapy; however, hypereosinophilia recurred 5 months later in association with myeloblastic bone marrow infiltration and without evidence of lymphoblastic lymphoma relapse. Cytogenetic analysis of the bone marrow showed a complex translocation involving chromosomes 7, 12, and 16. A rearrangement of ETV6 gene (12p13) was demonstrated by FISH studies, thus confirming the clonality of this population. The association of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia has been described in disorders with FGFR1 rearrangements. We hypothesize that other clonal eosinophilic disorders lacking this rearrangement could behave in a similar fashion through different pathogenic mechanisms.
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spelling pubmed-36546312013-05-24 Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature Moita, Filipa Bogalho, Isabel Alaiz, Helena Parreira, Joana Frade, Maria Jesus Nunes, Albertina Gomes da Silva, Maria Case Rep Hematol Case Report Hypereosinophilia, either clonal or reactive, has been described in association with multiple hematological malignancies. We describe a case of a patient presenting with hypereosinophilia that evolved into T-cell lymphoblastic lymphoma. Complete remission was achieved with chemotherapy; however, hypereosinophilia recurred 5 months later in association with myeloblastic bone marrow infiltration and without evidence of lymphoblastic lymphoma relapse. Cytogenetic analysis of the bone marrow showed a complex translocation involving chromosomes 7, 12, and 16. A rearrangement of ETV6 gene (12p13) was demonstrated by FISH studies, thus confirming the clonality of this population. The association of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia has been described in disorders with FGFR1 rearrangements. We hypothesize that other clonal eosinophilic disorders lacking this rearrangement could behave in a similar fashion through different pathogenic mechanisms. Hindawi Publishing Corporation 2013 2013-04-21 /pmc/articles/PMC3654631/ /pubmed/23710385 http://dx.doi.org/10.1155/2013/652745 Text en Copyright © 2013 Filipa Moita et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Moita, Filipa
Bogalho, Isabel
Alaiz, Helena
Parreira, Joana
Frade, Maria Jesus
Nunes, Albertina
Gomes da Silva, Maria
Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
title Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
title_full Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
title_fullStr Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
title_full_unstemmed Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
title_short Clonal Hypereosinophilia with ETV6 Rearrangement Evolving to T-Cell Lymphoblastic Lymphoma: A Case Report and Review of the Literature
title_sort clonal hypereosinophilia with etv6 rearrangement evolving to t-cell lymphoblastic lymphoma: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654631/
https://www.ncbi.nlm.nih.gov/pubmed/23710385
http://dx.doi.org/10.1155/2013/652745
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